Safe nutrient supplement - vitamin K2

2022-02-23 15:06 上海味庆

Introduction to vitamin K2

Vitamin K, also known as coagulation vitamin, is a kind of vitamin with the biological activity of chlorophylquinone. It was first discovered and extracted from animal liver and sesame oil by Danish chemist Dame in 1929. In 1934, it was named "vitamin K" from the German word "coagulation" - koagulation. In 1939, vitamin K was isolated from doyce in the United States, and its chemical formula and structure were determined. In 1943, they won the Nobel Prize in physiology and medicine.

Characteristics and functions of K2


Coagulation activity

Vitamin K is an essential substance for the synthesis of four coagulation proteins (prothrombin, transformation accelerating factor, anti hemophilia factor and stu factor) in the liver γ- The synthesis of carboxyglutamic acid plays an auxiliary role. If vitamin K is deficient, the above four coagulation factors synthesized by the liver are abnormal protein molecules, and the ability to catalyze coagulation will be greatly reduced.

Vitamin K2 has the same coagulation function and physiological function as vitamin K1. It can promote the synthesis of prothrombin (i.e. coagulation factor II) in the liver and regulate the synthesis of three other coagulation factors (VII, IX and x). Its coagulation mechanism is as glutamate- γ- A coenzyme of carboxylase that carboxylates glutamate residues in prothrombin to γ- Carboxylated glutamic acid residues (gamma carboxyglutamate, abbreviated as GLA) have the ability to bind Ca2 +, and connect the phospholipid surface and regulatory proteins, with coagulation activity. Vitamin K deficiency, the synthesis of factors II, VII, IX and X stays in the precursor state, and the prothrombin time is prolonged, which is easy to cause bleeding.

The health and Family Planning Commission has approved the fortification of vitamin K2 in the milk powder prepared for children and pregnant women, so as to avoid the bleeding symptoms caused by the deficiency of vitamin K in children and newborns due to the development of the coagulation system or lack of diet.


Effects on bone health

The effect of vitamin K2 on bone health has attracted more and more attention of scientists. A large number of clinical trials have proved that vitamin K2 supplementation has a positive effect on bone health. The GLA containing proteins in calcified tissues of the body mainly include bone gla protein (abbreviated as BGP or osteocalcin, abbreviated as OC), matrix γ- Carboxyl glutamate protein (MGP) and protein S. Vitamin K2 as glutamate- γ- The coenzyme of carboxylase can carboxylate the glutamic acid residue on osteocalcin into gla. After carboxylation, osteocalcin is activated, and GLA binds and deposits with calcium hydroxyapatite to promote bone mineralization. The lack of vitamin K2 in the body will lead to the incomplete carboxylation of osteocalcin and the formation of undercarboxylated Osteocalcin (ucOC). The glutamic acid residues with incomplete carboxylation will affect the mineralization of bone. In recent years, the relationship between the carboxylation degree of osteocalcin and bone health has attracted extensive attention in the study of bone metabolism biochemical indicators. UcOC content is proportional to osteoporosis and fracture probability, so ucOC can predict the occurrence of hip fracture. Serum ucOC increases with age, especially in early postmenopausal women. Vitamin K2 supplementation in diet can reduce serum ucOC and reduce fracture.


Prevention of vascular sclerosis

Matrix Gla protein (MGP) is a vitamin K-dependent gla protein synthesized in cartilage and vascular wall cells. This protein is an important inhibitor of arterial calcification and its activity depends on vitamin K-dependent γ- Glutamic acid carboxylation. Deficiency of vitamin K2 can lead to incomplete carboxylation of MGP (ucmgp), which leads to the loss of biological function of this protein. Uncarboxylated MGP can not effectively transport calcium ions in blood, resulting in an increase in blood calcium concentration, thus causing calcification of blood vessels.


Tumor suppressive effect

Studies have shown that vitamin K2 has a positive effect on the inhibition of liver cancer. In many studies of liver cancer, vitamin K2 can reduce the recurrence rate of liver cancer and improve the survival rate of patients. It has also been found that myeloma cells, leukemia cells and gastric adenocarcinoma cells are sensitive to vitamin K2. Vitamin K2 can effectively inhibit the growth of tumor cells and induce apoptosis is one of its important mechanisms. At present, there is no report of tumor suppressive effect of vitamin K1.


New findings in Alzheimer's disease

Researchers from the University of Northern Illinois in the United States found through Drosophila experiments that vitamin K2 can improve the electron transport in mitochondria, so it can restore the damaged mitochondria in cells to normal, and then promote energy production. This is expected to solve the interference of mitochondria and electron transmission in Alzheimer's disease patients and relieve the disease. Vitamin K1 has not been found in this respect.


Application of peripheral nerve

As a coenzyme, vitamin K can participate in the electron transport and redox process in cells and tissues, and has a gentle and relaxing effect on peripheral nerves and muscle tissues.




项目 Item指标 Specification


Content of vitamin K2



顺式 MK-7含量,%

Content of CIS-MK-7




项目 Item指标 Specification


Content of vitamin K2



顺式 MK-7含量,%

Content of CIS-MK-7




物料剂型 Formulations

包装规格 Packaging size


Vitamin K2Fermentation Method)powder


1kg × 10 bags / box


5kg × 2 bags / box


Vitamin K2(Fermentation Method)Oil


1kg × 6 bottles / box


15kg   bottle / box

quality guarantee period

It shall be stored in a dark, cool, dry and ventilated place with a shelf life of 24 months.

Production and quality control

Maiqili brand vitamin K2 (MK-7) is produced by Angel yeast Co., Ltd. entrusted by Hubei Meiqi Health Technology Co., Ltd.

Angel yeast Co., Ltd. was established in 1986, specializing in the processing and manufacturing of yeast and yeast derivatives. Its production and sales scale ranks first in Asia and third in the world. It has established a global marketing network, established regional headquarters and application technology service centers in Beijing, Shanghai, Chengdu, Shenyang, Wuhan, Guangzhou, Cairo and other cities, and exported products to more than 150 countries and regions.

Angel yeast Co., Ltd. has passed ISO9001 quality management system certification, HACCP certification, GMP certification and kosher certification, and the testing center has passed CNAs certification, providing a reliable guarantee for the production of products.